Article

The CD19 CAR T hinge region influences avidity and cytotoxicity in CD19 SNP variants in B-cell Lymphoma

2026-03-03

Abstract excerpt

<title>Abstract</title> <p>Outcomes after CD19 CAR T-cell therapy in patients with diffuse large B-cell lymphoma are variable, partly influenced by the germline CD19 SNP rs2904880 (V174/L174). Using structural modeling, lymphoma cell lines, and patient data, we demonstrate that CAR hinge choice (CD8 versus CD28) differentially modulates avidity and cytotoxicity against CD19 V174 and V174L variants and correlates...

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Literature Corpus work: 116371ad-9d79-5bc7-bf4c-c43c03bcfd4d
DOI: 10.21203/rs.3.rs-8865828/v1

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