Article

Microphthalmia and disrupted retinal development due to a <i>LacZ</i> knock-in/knock-out allele at the <i>Vsx2</i> locus

2024-06-08

Abstract excerpt

Visual System Homeobox 2 ( Vsx2 ) is a transcription factor expressed in the developing retina that regulates tissue identity, growth, and fate determination. Several mutations in the Vsx2 gene exist in mice, including a spontaneous nonsense mutation and two targeted missense mutations originally identified in humans. Here, we expand the genetic repertoire to include a LacZ reporter allele ( Vsx2 LacZ ) desig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 024a814d-724f-5812-ae33-2d0de89582ce
DOI: 10.1101/2024.06.08.597937

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microphthalmia and disrupted retinal development due to a <i>LacZ</i> knock-in/knock-out allele at the <i>Vsx2</i> locusDOI 10.1101/2024.06.08.597937Read

Mutation of Vsx genes in zebrafish highlights the robustness of the retinal specification networkSemantic proximity Read

Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network.Semantic proximity Read

Identification of Evolutionarily Conserved VSX2 Enhancers in Retinal DevelopmentSemantic proximity Read

Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding.Semantic proximity Read

Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.Semantic proximity Read

<i>SOX2</i> mutation causes anophthalmia, hearing loss, and brain anomaliesSemantic proximity Read

Single cell profiling of CRISPR/Cas9-induced OTX2 deficient retinas reveals fate switch from restricted progenitorsSemantic proximity Read

<i>RS-1</i>Gene Delivery to an Adult<i>Rs1h</i>Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked RetinoschisisSemantic proximity Read

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.Semantic proximity Read

Pou4f2 knock-in Cre mouse: A multifaceted genetic tool for vision researchers.Semantic proximity Read

Ocular abnormalities in mice lacking the Ski proto-oncogene.Semantic proximity Read

Humanized Kcnv2 E151X Mouse Captures Hallmarks of KCNV2-Associated Retinal DystrophySemantic proximity Read