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Article

Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.

Stem cells (Dayton, Ohio) - 1 Jun 2014

Phillips M Joseph, Perez Enio T, Martin Jessica M, Reshel Samantha T, Wallace Kyle A, Capowski Elizabeth E, Singh Ruchira, Wright Lynda S, Clark Eric M, Barney Patrick M, Stewart Ron, Dickerson Sarah J, Miller Michael J, Percin E Ferda, Thomson James A, Gamm David M

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) have been shown to differentiate along the retinal lineage in a manner that mimics normal mammalian development. Under certain culture conditions, hiPSCs form optic vesicle-like structures (OVs), which contain proliferating progenitors capable of yielding all neural retina (NR) cell types over time. Such observations imply conserved roles for regulators of...

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Identifiers

PMID: 24532057
DOI: 10.1002/stem.1667
PMCID: PMC4037340

Genes

VSX2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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