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Article

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes.

International journal of molecular sciences - 30 May 2021

Chirivì Maila, Maiullari Fabio, Milan Marika, Presutti Dario, Cordiglieri Chiara, Crosti Mariacristina, Sarnicola Maria Lucia, Soluri Andrea, Volpi Marina, Święszkowski Wojciech, Prati Daniele, Rizzi Marta, Costantini Marco, Seliktar Dror, Parisi Chiara, Bearzi Claudia, Rizzi Roberto

Abstract excerpt

The immune system is a fine modulator of the tumor biology supporting or inhibiting its progression, growth, invasion and conveys the pharmacological treatment effect. Tumors, on their side, have developed escaping mechanisms from the immune system action ranging from the direct secretion of biochemical signals to an indirect reaction, in which the cellular actors of the tumor microenvironment (TME) collaborate...

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Identifiers

PMID: 34070750
DOI: 10.3390/ijms22115862
PMCID: PMC8198248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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