Article

Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency

2022-05-02

Abstract excerpt

The interphotoreceptor matrix (IPM) is a specialized extracellular mesh of molecules surrounding the inner and outer segments of photoreceptor neurons. Interphotoreceptor matrix proteoglycan 1 and 2 (IMPG1 and IMPG2) are major components of the IPM. Both proteoglycans possess SEA (sperm protein, enterokinase and agrin) domains, which may support proteolysis. Interestingly mutations in the SEA domains of IMPG1 and...

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Literature Corpus work: 021f4b57-a629-5519-8c61-323077006674
DOI: 10.1101/2022.04.27.489588

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