Article
Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 May 2020
Salido Ezequiel M, Ramamurthy Visvanathan
Abstract excerpt
Photoreceptor neurons are surrounded by an extracellular matrix, called the interphotoreceptor matrix (IPM). Activities crucial to vision occur within the IPM, including trafficking of nutrients and metabolites, retinal attachment, and interactions needed for normal outer segment phagocytosis. The IPM includes the following two unique proteoglycans: IPM proteoglycan 1 (IMPG1) and IMPG2. Patients with mutations in...
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