Article

Proteoglycan IMPG2 shapes the interphotoreceptor matrix and modulates vision

2019-11-29

Abstract excerpt

The extracellular matrix surrounding the photoreceptor neurons, interphotoreceptor matrix (IPM) is comprised of two unique proteoglycans: IP M p roteo g lycan 1 and 2 (IMPG1 and IMPG2). Although the functions of the IPM are not understood, patients with mutations in IMPG1/2 develop visual deficits with subretinal material accumulation. Here, we generated mouse models lacking IMPG1/2 to decipher the role of these...

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Literature Corpus work: 788064c6-d32a-5fb5-a663-f58fab9ca8a0
DOI: 10.1101/859116

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