Article

The α-Synuclein seeding assay discriminates between LRRK2 p.Gly2019Ser variant carriers with and without Parkinson’s disease

2026-05-17

Abstract excerpt

<h4>Background</h4> Reliable biomarkers for Parkinson’s disease (PD) pathology detection are essential for research. The α-synuclein (aSyn) seed amplification assay (SAA) is a validated biomarker for misfolded aSyn. <h4>Objectives</h4> To assess the association between aSyn SAA and LRRK2 -related PD ( LRRK2 -PD) and its link to mitochondrial genetic burden. <h4>Methods</h4> We included N=76 LRRK2 p.Gly2019Se...

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Literature Corpus work: 021299c6-5099-5950-abd1-376ddb6ab255
DOI: 10.64898/2026.05.13.26353087

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