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Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice

26 Apr 2023

Abstract excerpt

BACKGROUND: Studies have shown that sperm-borne microRNAs (miRNAs) are involved in mammalian preimplantation embryonic development. In humans, spermatozoan miR-34c levels are correlated with in vitro fertilization outcomes, such as embryo quality and the clinical pregnancy and live birth rates. In rabbits and cows, miR-34c improves the developmental competence of embryos generated by somatic cell nuclear...

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PMID: 37101140
DOI: 10.1186/s12958-023-01089-3

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