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Article

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing.

Nature - 29 Aug 2013

Xue Zhigang, Huang Kevin, Cai Chaochao, Cai Lingbo, Jiang Chun-yan, Feng Yun, Liu Zhenshan, Zeng Qiao, Cheng Liming, Sun Yi E, Liu Jia-yin, Horvath Steve, Fan Guoping

Abstract excerpt

Mammalian pre-implantation development is a complex process involving dramatic changes in the transcriptional architecture. We report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing. Based on single-nucleotide variants in human blastomere messenger RNAs and paternal-specific single-nucleotide polymorphisms, we identify...

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Share to Gene Expression Regulation, Developmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Analysis, RNA

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Source

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Identifiers

PMID: 23892778
DOI: 10.1038/nature12364
PMCID: PMC4950944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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