Article

Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells

2026-06-04

Abstract excerpt

Tumours reshape their surrounding extracellular matrix (ECM), creating a microenvironment with altered chemical and mechanical properties. Integrins detect these changes, linking the ECM to the intracellular cytoskeleton and promoting cell survival, motility, invasion and differentiation, and further ECM remodelling. However, the molecular mechanisms by which tumours remodel their ECM are not well understood. Here...

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Literature Corpus work: 3fa07b7a-9e20-5806-be09-4256f911b7a1
DOI: 10.64898/2026.06.01.729048

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