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Article

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.

Kidney international - 1 Aug 2016

Subramanian Balajikarthick, Sun Hua, Yan Paul, Charoonratana Victoria T, Higgs Henry N, Wang Fang, Lai Ka-Man V, Valenzuela David M, Brown Elizabeth J, Schlöndorff Johannes S, Pollak Martin R

Abstract excerpt

Mutations in the INF2 (inverted formin 2) gene, encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause human focal segmental glomerulosclerosis (FSGS). INF2 interacts directly with certain other mammalian diaphanous formin proteins (mDia) that function as RhoA effector molecules. FSGS-causing INF2 mutations impair these interactions and disrupt the ability of INF2 to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27350175
DOI: 10.1016/j.kint.2016.04.020
PMCID: PMC5363079

Genes

INF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.PMID 27350175Read ↗

INF2 mutations cause kidney disease through a gain-of-function mechanism.Semantic proximity Read ↗

Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the GlomerulusSemantic proximity Read ↗

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosisSemantic proximity Read ↗

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin SignalingSemantic proximity Read ↗

Missense Mutant Gain-of-Function Causes Inverted Formin 2 (INF2)-Related Focal Segmental Glomerulosclerosis (FSGS)Semantic proximity Read ↗

Clinical and Pathological Heterogeneity in FSGS due to INF2 MutationsSemantic proximity Read ↗

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.Semantic proximity Read ↗

Dysregulated Dynein-Mediated Trafficking of Nephrin Causes INF2-related Podocytopathy.Semantic proximity Read ↗

Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis.Semantic proximity Read ↗

The formin INF2 in disease: progress from 10 years of research.Semantic proximity Read ↗

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosisSemantic proximity Read ↗

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).Semantic proximity Read ↗

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