Article

Pyk2 Overexpression in Postsynaptic Neurons Blocks Aβ <sub>1-42</sub> -induced Synaptotoxicity in a Microfluidic Co-Culture Model

2019-12-21

Abstract excerpt

Recent meta-analyses of genome-wide association studies identified a number of genetic risk factors of Alzheimer’s disease; however, little is known about the mechanisms by which they contribute to the pathological process. As synapse loss is observed at the earliest stage of Alzheimer’s disease, deciphering the impact of Alzheimer’s risk genes on synapse formation and maintenance is of great interest. In this pap...

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Literature Corpus work: 01e3e89d-9747-52e4-be3f-cbf6a312d697
DOI: 10.1101/2019.12.20.884205

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