Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.

doi:10.3109/08916934.2012.750301

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Article

Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.

Autoimmunity - 1 Mar 2013

Sun Yonglian, Peng Ivan, Senger Kate, Hamidzadeh Kajal, Reichelt Mike, Baca Miriam, Yeh Ronald, Lorenzo Maria N, Sebrell Andrew, Dela Cruz Christopher, Tam Lucinda, Corpuz Racquel, Wu Jiansheng, Sai Tao, Roose-Girma Merone, Warming Søren, Balazs Mercedesz, Gonzalez Lino C, Caplazi Patrick, Martin Flavius, Devoss Jason, Zarrin Ali A

Abstract excerpt

Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder caused by chronic inflammation and demyelination within the central nervous system (CNS). Clinical studies in MS patients have demonstrated efficacy with B cell targeted therapies such as anti-CD20. However, the exact role that B cells play in the disease process is unclear. Activation Induced cytidine deaminase (AID) is an essential enzyme for...

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PMID: 23167594
DOI: 10.3109/08916934.2012.750301
PMCID: PMC3581050

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