Article

Comparative Study of BBB-Targeting AAV Capsids on Central Nervous System Delivery Efficiency

2026-02-04

Abstract excerpt

<title>Abstract</title> <p> The efficacy of adeno-associated virus (AAV)-mediated systemic gene therapy for central nervous system (CNS) diseases is often limited by the blood-brain barrier (BBB). This study systematically evaluated the tissue distribution of three BBB-crossing AAV capsid variants (PHP.eB, CNSRCV300, and BI-hTFR1) following intravenous injection in mice, using either a constitutive promoter (CAG...

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Literature Corpus work: 16181cbd-b11e-5eb5-89c4-9827b6908703
DOI: 10.21203/rs.3.rs-8716281/v1

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