Article

LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model

2023-04-17

Abstract excerpt

Background: Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease inhibitor consisting of multiple domains. A loss of function mutation is described in Netherton patients that show severe symptoms of atopic lesions and itch. <h4>Objectives:</h4> LEKTI domain 6 (LD6) has shown strong serine protease-inhibitory action in in vitro assays and thus it was tested in vitro and in vivo for potenti...

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Literature Corpus work: 01ad4536-62b3-5417-accc-b49c56aeca29
DOI: 10.22541/au.168170955.51009089/v1

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