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Article

Cathelicidin represents a new target for manipulation of skin inflammation in Netherton syndrome.

Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2020

Zingkou Eleni, Pampalakis Georgios, Sotiropoulou Georgia

Abstract excerpt

Netherton syndrome (NS) is a severe ichthyosis caused by inactivating mutations in the SPINK5 gene encoding the serine protease inhibitor LEKTI. Spink5-/- mice recapitulate NS and die perinatally from extensive dehydration as a result of a severe defect of the epidermal barrier. We showed that deletion of Klk5 in Spink5-/- rescues neonatal lethality (Furio et al., 2015). However, Spink5-/-Klk5-/- mice developed...

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Source

Identifiers

PMID: 32442469
DOI: 10.1016/j.bbadis.2020.165831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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