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Article

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.

Investigative ophthalmology & visual science - 1 Aug 2023

Galletti Jeremias G, Scholand Kaitlin K, Trujillo-Vargas Claudia M, Haap Wolfgang, Santos-Ferreira Tiago, Ullmer Christoph, Yu Zhiyuan, de Paiva Cintia S

Abstract excerpt

Purpose: Aged C57BL/6J (B6) mice have increased levels of cathepsin S, and aged cathepsin S (Ctss-/-) knockout mice are resistant to age-related dry eye. This study investigated the effects of cathepsin S inhibition on age-related dry eye disease. Methods: Female B6 mice aged 15.5 to 17 months were randomized to receive a medicated diet formulated by mixing the RO5461111 cathepsin S inhibitor or a standard diet...

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Identifiers

PMID: 37540176
DOI: 10.1167/iovs.64.11.7
PMCID: PMC10414132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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