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Article

Immunological phenotype and skin modeling of Netherton syndrome.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG - 1 Dec 2025

Süßmuth Kira, Traupe Heiko, Wittkowski Helmut, Fischer Judith, Oji Vinzenz, Bodes Jacqueline

Abstract excerpt

Netherton syndrome (NTS) is a syndromic ichthyosis characterized by scaling, erythroderma, and proneness towards allergies and infections. It is caused by mutations in the SPINK5 gene, encoding the lympho-epithelial Kazal-type 5 related inhibitor (LEKTI), which regulates the activity of kallikreins in the skin. Treatment options are limited, insufficient, time-consuming and a financial burden for the patients. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteinase Inhibitory Proteins, Secretory

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Source

Identifiers

PMID: 41126693
DOI: 10.1111/ddg.15928

Genes

NTS
SPINK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Immunological phenotype and skin modeling of Netherton syndrome.PMID 41126693Read ↗

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