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Article

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation

6 Sept 2018

Abstract excerpt

An altered response to DNA damage is commonly associated with genomic instability, a hallmark of cancer. Fumarate hydratase (FH) was recently characterised as a DNA repair factor required in non-homologous end-joining (NHEJ) through the local production of fumarate. Inactivating germline mutations in FH cause hereditary leiomyomatosis and renal cell cancer (HLRCC), a cancer syndrome characterised by accumulation...

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PMID: 30190474
DOI: 10.1038/s41419-018-0912-3

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