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Anti-Carbamylated Protein Antibody Identifies Seronegative Early Rheumatoid Arthritis Missed by Anti-CCP, Independently Predicts Joint Deformity, and Extends ACR/EULAR Classification: A Dose-Response and Bootstrap-Validated Cross-Sectional Study from North India

2026-06-02

Abstract excerpt

<title>Abstract</title> <p>Background Anti-cyclic citrullinated peptide (anti-CCP) antibodies miss 30–50% of early rheumatoid arthritis (RA) presentations, delaying treatment and permitting structural damage. Anti-carbamylated protein (anti-CarP) antibodies target homocitrullinated proteins via an HLA-DRB1 shared-epitope-independent pathway biochemically distinct from anti-CCP, making them candidates to fill thi...

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Literature Corpus work
0197863c-c722-5bde-b509-4ae3868fc930
DOI
10.21203/rs.3.rs-9782080/v1
Open publication

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Anti-Carbamylated Protein Antibody Identifies Seronegative Early Rheumatoid Arthritis Missed by Anti-CCP, Independently Predicts Joint Deformity, and Extends ACR/EULAR Classification: A Dose-Response and Bootstrap-Validated Cross-Sectional Study from North IndiaDOI 10.21203/rs.3.rs-9782080/v1
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