Article
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.
Annals of the rheumatic diseases - 1 Mar 2015
Wagner Catriona A, Sokolove Jeremy, Lahey Lauren J, Bengtsson Camilla, Saevarsdottir Saedis, Alfredsson Lars, Delanoy Michelle, Lindstrom Tamsin M, Walker Roger P, Bromberg Reuven, Chandra Piyanka E, Binder Steven R, Klareskog Lars, Robinson William H
Abstract excerpt
INTRODUCTION: A hallmark of rheumatoid arthritis (RA) is the development of autoantibodies targeting proteins that contain citrulline. Anticitrullinated protein antibodies (ACPAs) are currently detected by the commercial cyclic citrullinated peptide (CCP) assay, which uses a mix of cyclised citrullinated peptides as an artificial mimic of the true antigen(s). To increase the sensitivity of ACPA detection and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.