Article
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial.
Annals of the rheumatic diseases - 14 Nov 2024
Lend Kristina, Lampa Jon, Padyukov Leonid, Hetland Merete Lund, Heiberg Marte Schrumpf, Nordström Dan C, Nurmohamed Michael T, Rudin Anna, Østergaard Mikkel, Haavardsholm Espen A, Hørslev-Petersen Kim, Uhlig Till, Sokka-Isler Tuulikki, Gudbjornsson Bjorn, Grondal Gerdur, Frazzei Giulia, Christiaans Jeroen, Wolbink Gertjan, Rispens Theo, Twisk Jos W R, van Vollenhoven Ronald F
Abstract excerpt
OBJECTIVES: To investigate whether rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and shared epitope (SE) allele-related genetic markers associate with treatment response to abatacept, certolizumab pegol or tocilizumab versus active conventional treatment (ACT). METHODS: Patients with treatment-naïve early rheumatoid arthritis were randomised in the NORD-STAR trial to ACT, certolizumab...
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