Article
Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency.
Arthritis research & therapy - 19 Oct 2020
Iwasaki Takeshi, Nakabo Shuichiro, Terao Chikashi, Murakami Kosaku, Nakashima Ran, Hashimoto Motomu, Imura Yoshitaka, Yukawa Naoichiro, Yoshifuji Hajime, Miura Yasuo, Yurugi Kimiko, Maekawa Taira, van Delft Myrthe A M, Trouw Leendert A, Fujii Takao, Mimori Tsuneyo, Ohmura Koichiro
Abstract excerpt
BACKGROUND: The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may ultimately develop RA. We retrospectively investigated whether anti-CCP-positive non-RA CTD patients developed RA and attempted to identify factors that may differentiate...
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