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Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy

11 Oct 2010

Abstract excerpt

Human Ads (adenoviruses) have been extensively utilized for the development of vectors for gene transfer, as they infect many cell types and do not integrate their genome into host-cell chromosomes. In addition, they have been widely studied as cytolytic viruses, termed oncolytic adenoviruses in cancer therapy. Ads are non-enveloped viruses with a linear double-stranded DNA genome of 30-38 kb which encodes 30-40...

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PMID: 20937040
DOI: 10.1042/bj20100766

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