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A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions

1 Mar 2022

Abstract excerpt

To develop adenoviral cell- or tissue-specific gene delivery, understanding of the infection mechanisms of adenoviruses is crucial. Several adenoviral attachment proteins such as CD46, CAR and sialic acid have been identified and studied. However, most receptor studies were performed on non-human cells. Combining our reporter gene-tagged adenovirus library with an in vitro human gene knockout model, we performed...

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PMID: 35269463
DOI: 10.3390/cells11050841

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