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Adenovirus type-35 vectors block human CD4 <sup>+</sup> T-cell activation via CD46 ligation

18 Apr 2011

Abstract excerpt

Recombinant adenoviruses (rAds) based on types 5 (rAd5) and 35 (rAd35) have emerged as important vaccine delivery vectors in clinical testing for a variety of pathogens. A major difference between these vectors is their binding to cellular receptors used for infection. Whereas rAd5 binds coxsackie-adenovirus receptor (CAR), rAd35 binds the complement regulatory protein CD46. Although rAd35 infected and...

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PMID: 21502499
DOI: 10.1073/pnas.1017146108

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