Article

ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity

2026-07-17

Abstract excerpt

<h4>Summary</h4> Natural Killer (NK) cell desensitization induced by persistent stimulation limits durable antitumor immunity, yet the molecular mechanisms governing this dysfunctional state remain poorly defined. To identify conserved regulators of NK cell desensitization, we performed comparative transcriptomic analyses across multiple murine models of persistent activation and dysfunction. This approach define...

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Literature Corpus work: 01669372-6120-57f5-b19a-87d975bdbf0e
DOI: 10.64898/2026.07.12.738073

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