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Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer

24 Jan 2025

Abstract excerpt

BACKGROUND: Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RNAs (circRNAs) have emerged as key regulators of the metastasis of various cancers. However, the functional effects and regulatory mechanisms of circRNAs in metastatic CRPC (mCRPC) remain largely unknown. METHODS: The expression of circBNC2 in prostate cancer (PCa), CRPC and...

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PMID: 39856701
DOI: 10.1186/s12943-025-02234-9

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