Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013
Penchala Sravan C, Connelly Stephen, Wang Yu, Park Miki S, Zhao Lei, Baranczak Aleksandra, Rappley Irit, Vogel Hannes, Liedtke Michaela, Witteles Ronald M, Powers Evan T, Reixach Natàlia, Chan William K, Wilson Ian A, Kelly Jeffery W, Graef Isabella A, Alhamadsheh Mamoun M
Abstract excerpt
The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidoses, which are most commonly caused by aggregation of Ig light chains or transthyretin (TTR) in the cardiac interstitium and conducting system, represent an important and often underdiagnosed cause of heart failure. Two types of TTR-associated amyloid...
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