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Article

Highly diverged non-vertebrate Ki-67 proteins with conserved biophysical and functional properties

2026-06-19

Abstract excerpt

The Ki-67 protein is a widely used marker of mammalian cell proliferation that plays critical roles in heterochromatin organisation and mitotic perichromosomal layer formation. Thus, its apparent restriction to vertebrates is puzzling. However, sequences with limited homology to subdomains of Ki-67 are present in genomes from some non-vertebrate species. Here, using structural modelling, biophysical and functional...

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Literature Corpus work
deaf718f-84b3-5b3e-a80e-0bca775ff01e
DOI
10.64898/2026.06.18.733134
Open publication

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Highly diverged non-vertebrate Ki-67 proteins with conserved biophysical and functional propertiesDOI 10.64898/2026.06.18.733134
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