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Article

Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2017

Knudsen Erik S, Vail Paris, Balaji Uthra, Ngo Hoai, Botros Ihab W, Makarov Vladimir, Riaz Nadeem, Balachandran Vinod, Leach Steven, Thompson Debrah M, Chan Timothy A, Witkiewicz Agnieszka K

Abstract excerpt

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with an immunosuppressive milieu that supports immune system evasion and disease progression. Here, we interrogated genetic, stromal, and immunologic features of PDAC to delineate impact on prognosis and means to more effectively employ immunotherapy.Experimental Design: A cohort of 109 PDAC cases annotated for overall survival was utilized as a...

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Share to Antigens, Differentiation, Myelomonocytic
Share to B7-H1 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Pancreatic Ductal

Share to CD163 Antigen

Share to CD8-Positive T-Lymphocytes

Share to CTLA-4 Antigen

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Source

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Identifiers

PMID: 28348045
DOI: 10.1158/1078-0432.CCR-17-0162
PMCID: PMC5951386

Genes

CTLA4
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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