Article
Oncogenic dependency plays a dominant role in the immune response to cancer.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2023
Li Jinyu, D'Amico Stephen, Kirillov Varvara, Petrenko Oleksi, Reich Nancy C
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies. Advanced PDAC is considered incurable. Nearly 90% of pancreatic cancers are caused by oncogenic KRAS mutations. The mechanisms of primary or acquired resistance to KRAS inhibition are currently unknown. Here, we propose that oncogenic dependency, rather than KRAS mutation per se, plays a dominant role in the immune response to...
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