Article

PvDBP gene amplification is associated with functional immune evasion by Plasmodium vivax in vivo

2026-04-07

Abstract excerpt

<title>Abstract</title> <p> The key ligand involved in <italic>Plasmodium vivax</italic> reticulocyte invasion is the Duffy Binding Protein (PvDBP) which binds the Duffy receptor on reticulocytes. Anti-PvDBP human monoclonal antibodies can inhibit PvDBP-Duffy receptor binding and neutralize reticulocytes invasion <italic>in vitro</italic> . However, parasites with multiple copies of the <italic>pvdbp</itali...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0113ff80-54b6-58a8-ba1d-f38f299d39a7
DOI: 10.21203/rs.3.rs-9081241/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PvDBP gene amplification is associated with functional immune evasion by Plasmodium vivax in vivoDOI 10.21203/rs.3.rs-9081241/v1Read

Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunitySemantic proximity Read

Genetic diversity in two <i>Plasmodium vivax</i> protein ligands for reticulocyte invasionSemantic proximity Read

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene DuplicationsSemantic proximity Read

Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasionSemantic proximity Read

Frequent expansion of <i>Plasmodium vivax</i> Duffy Binding Protein in Ethiopia and its epidemiological significanceSemantic proximity Read

Duffy Binding Protein Ligand (PvDBP) gene duplication in Indian P. Vivax Malaria isolates: implication for malaria research.Semantic proximity Read

Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significanceSemantic proximity Read

Whole Genome Sequencing of <i>Plasmodium vivax</i> Isolates Reveals Frequent Sequence and Structural Polymorphisms in Erythrocyte Binding GenesSemantic proximity Read

Comparative transcriptomics reveal differential gene expression in <i>Plasmodium vivax</i> geographical isolates and implications on erythrocyte invasion mechanismsSemantic proximity Read

Copy number variations of <i>Plasmodium vivax DBP1</i> , <i>EBP/DBP2</i> , and <i>RBP2b</i> in Duffy-positive and Duffy-negative EthiopiansSemantic proximity Read

Alternative Invasion Mechanisms and Host Immune Response to Plasmodium vivax Malaria: Trends and Future DirectionsSemantic proximity Read

High prevalence of mixed <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> co-infections in Duffy negative individuals in EthiopiaSemantic proximity Read