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Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance

11 Sept 2019

Abstract excerpt

Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence...

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PMID: 31509523
DOI: 10.1371/journal.pntd.0007222

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