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Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion

22 Oct 2018

Abstract excerpt

The interaction between Plasmodium vivax Duffy binding protein (PvDBP) and Duffy antigen receptor for chemokines (DARC) has been described as critical for the invasion of human reticulocytes, although increasing reports of P. vivax infections in Duffy-negative individuals questions its unique role. To investigate the genetic diversity of the two main protein ligands for reticulocyte invasion, PvDBP and P. vivax...

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PMID: 30346980
DOI: 10.1371/journal.pntd.0006555

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