Article

Bacterial Peptidoglycan Stapling with Functionalized D-Amino Acids

2019-11-12

Abstract excerpt

Transpeptidation reinforces the structure of cell wall peptidoglycan, an extracellular heteropolymer that protects bacteria from osmotic lysis. The clinical success of transpeptidase-inhibiting β-lactam antibiotics illustrates the essentiality of these cross-linkages for cell wall integrity, but the presence of multiple, seemingly redundant transpeptidases in many bacterial species makes it challenging to determin...

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Literature Corpus work: 0103720f-bf82-58c8-845e-4f34c3ea33e1
DOI: 10.26434/chemrxiv.10248764.v1

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