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Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

2022-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of Kras G12D -driven PDAC in mice is accelerated by deleting Plk3 , explaining the often reduced Plk3 expression in human PDAC. Importantly, a 41 kDa Plk3 (p41Plk...

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Literature Corpus work
00dfdff7-f8d6-5dba-b4a0-ebfa102a7de9
DOI
10.1101/2022.07.28.501759
Open publication

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Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic CancerDOI 10.1101/2022.07.28.501759
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