AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.

doi:10.1053/j.gastro.2021.07.030

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Article

AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.

Gastroenterology - 1 Nov 2021

Zhang Zhiheng, Li Hongzhen, Deng Yibin, Schuck Kathleen, Raulefs Susanne, Maeritz Nadja, Yu Yuanyuan, Hechler Torsten, Pahl Andreas, Fernández-Sáiz Vanesa, Wan Yuan, Wang Guosheng, Engleitner Thomas, Öllinger Rupert, Rad Roland, Reichert Maximilian, Diakopoulos Kalliope N, Weber Verena, Li Jingjing, Shen Shanshan, Zou Xiaoping, Kleeff Jörg, Mihaljevic Andre, Michalski Christoph W, Algül Hana, Friess Helmut, Kong Bo

Abstract excerpt

BACKGROUND & AIMS: Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia. Anterior gradient 2 (Agr2), a known inhibitor of p53, is detected at early stage of pancreatic ductal adenocarcinoma (PDAC) development. RNA polymerase II (RNAPII) is a key nuclear enzyme; regulation of its nuclear...

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PMID: 34303658
DOI: 10.1053/j.gastro.2021.07.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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