Article

Aberrant STAT3 signaling in pancreatic cancer requires the lncRNA NEAT1 regulated by the metalloprotease-disintegrin ADAM8 via miR-181a-5p

2024-07-03

Abstract excerpt

<title>Abstract</title> <p>Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Several studies demonstrate that ADAM8 and STAT3 are critical for PDAC progression and potential therapeutic targets. Methods TGCA, microarray, and immunohistochemistry data from a PDAC cohort were used for clinical analyses. Panc89 cells with ADAM8 knockout, re-expression of ADAM8 mutants, and Panc1 ce...

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Literature Corpus work: 750ef68d-76a7-51e8-bccf-bf468e4ebaa0
DOI: 10.21203/rs.3.rs-4582104/v1

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