Article

Altered resting-state functional connectivity in hiPSC-derived neuronal networks from schizophrenia patients

2021-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Schizophrenia (SZ) is a complex mental disease thought to arise from abnormal neurodevelopment, characterized by an altered reality perception and widely associated with brain connectivity anomalies. Previous work has shown disrupted resting-state brain functional connectivity (FC) in SZ patients. We used Human Induced Pluripotent Stem Cells (hiPSC)-derived neuronal cultures to study SZ’s neural...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 009a830d-dfbe-57ef-b2e1-55c74516844f
DOI: 10.1101/2021.08.26.21262277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered resting-state functional connectivity in hiPSC-derived neuronal networks from schizophrenia patientsDOI 10.1101/2021.08.26.21262277Read

NeuroMark-SZ: A Holistic Resting-State-fMRI-Based Model for Divergent Functional Circuitry in SchizophreniaSemantic proximity Read

In vitro reconstitution of hippocampal cell assembliesSemantic proximity Read

Schizophrenia hiPSC neurons display expression changes that are enriched for disease risk variants and a blunted activity-dependent responseSemantic proximity Read

Transient patterns of functional dysconnectivity in youth with psychosis spectrum symptomsSemantic proximity Read

A computational framework linking molecular regulation, synaptic plasticity, and brain disordersSemantic proximity Read

Hypersynchronous iPSC-derived <i>SHANK2</i> neuronal networks are rescued by mGluR5 agonismSemantic proximity Read

Nested oscillatory dynamics in cortical organoids model early human brain network developmentSemantic proximity Read

Mapping Individualized Dual-Axis Network Topology in Focal Epilepsy: Divergent Alterations in System Integrity, Integration, and Clinical CorrelatesSemantic proximity Read

Reproducible Coactivation Patterns of Functional Brain Networks Reveal the Aberrant Dynamic State Transition in SchizophreniaSemantic proximity Read

Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and its Links to Genetic RiskSemantic proximity Read

Spontaneous Neuronal Network Persistent Activity in the Neocortex: A(n) (Endo)phenotype of Brain (Patho)physiology.Semantic proximity Read

Time-Resolved Neuronal Network Dynamics Distinguish Pathological States in Organoid ModelsSemantic proximity Read