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Childhood Trauma and<i>APOEε4</i>are Associated with Adolescent Brain Function, Posttraumatic Stress, and Alcohol-related Outcomes

2025-05-06

Abstract excerpt

Childhood trauma affects neurodevelopment and lifelong risk for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Changes in brain structures and function are observed in young carriers of APOEε4 , the genetic factor most associated with Alzheimer’s disease. Longitudinal studies of APOEε4 , childhood trauma, and neural connectivity in adolescence have not been explored. We studied 837 trauma-exp...

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Literature Corpus work
008dd797-2b2a-52fb-b046-c2674487e44e
DOI
10.1101/2025.05.02.25326879
Open publication

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