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Article

Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study.

Brain and behavior - 1 Dec 2020

Tian Tian, Li Jia, Zhang Guiling, Wang Jian, Liu Dong, Wan Changhua, Fang Jicheng, Wu Di, Zhou Yiran, Zhu Wenzhen

Abstract excerpt

Childhood adversity may act as a stressor to produce a cascade of neurobiological effects that irreversibly alter neural development, setting the stage for developing psychopathology in adulthood. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has received much attention as a candidate gene associated with environmental adversity, modifying risk for psychopathology. In this study, we aim to see...

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Identifiers

PMID: 32997444
DOI: 10.1002/brb3.1858
PMCID: PMC7749512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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