Article

Sperm derived H2AK119ub1 is required for embryonic development in <i>Xenopus laevis</i>

2024-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Deposition of H2AK119ub1 by the polycomb repressive complexe-1 plays a key role in the initiation of facultative heterochromatin formation in somatic cells. Here we evaluate the contribution of sperm derived H2AK119ub1 to embryo development. In Xenopus laevis we found that H2AK119ub1 is present during spermiogenesis and into early embryonic development, highlighting its credential for a role in...

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Literature Corpus work: 006fa32f-0d8b-5a99-946b-cf9ab3eb5a82
DOI: 10.1101/2024.04.23.590676

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