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Article

Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen.

Communications biology - 29 Apr 2024

Zhang Mengyu, Xu Wei, Luo Lingjie, Guan Fenghui, Wang Xiangyao, Zhu Pei, Zhang Jianhua, Zhou Xuyu, Wang Feng, Ye Sheng

Abstract excerpt

Neoantigens derived from somatic mutations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), the most frequently mutated oncogene, represent promising targets for cancer immunotherapy. Recent research highlights the potential role of human leukocyte antigen (HLA) allele A*11:01 in presenting these altered KRAS variants to the immune system. In this study, we successfully generate and identify murine T-cell...

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Identifiers

PMID: 38684865
DOI: 10.1038/s42003-024-06209-2
PMCID: PMC11058820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen.PMID 38684865Read ↗

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