Article

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

2024-02-06

Abstract excerpt

<h4>Summary</h4> Mutations in KRAS are some of the most common across multiple cancer types and are thus attractive targets for therapy. Recent studies demonstrated that mutant KRAS generates immunogenic neoantigens that can be targeted in adoptive T cell therapy in metastatic diseases. To expand mutant KRAS specific immunotherapies, it is critical to identify additional HLA-I allotypes that can present KRAS neoa...

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Literature Corpus work: 353e9998-d861-5e51-8dfe-ea04ad8fab2b
DOI: 10.1101/2024.02.01.578367

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