Article

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

2020-06-16

Abstract excerpt

KRAS codon 12 mutations are among the most common hotspot mutations in human cancer. Using a functional screening platform we set out to identify αβ T-cell receptors (TCRs) as potential targeting reagents for KRAS G12D and/or KRAS G12V neoepitopes presented by the prevalent HLA-A*02:01 allele. Here we describe isolation and characterization of three distinct CD8 + T cell clones from a pre-treated 76 year old pa...

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Literature Corpus work: fca2ac83-9793-582e-a664-59f5258b78d6
DOI: 10.1101/2020.06.15.149021

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Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutationsDOI 10.1101/2020.06.15.149021Read

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