Article

HIV-1 subtype C LTR Sp1IIIT5A mutant enhances transcription activity and Sp1 binding affinity

2025-01-24

Abstract excerpt

<h4>Background</h4> Genetic variation within HIV-1 subtype C (HIV-1C) long terminal repeat (LTR) transmitted/founder viruses influences transcription activation and clinical disease outcomes. The role of specific mutations such as thymine-to-adenine (T5A) mutation at position five of the Specificity protein 1 (Sp1) III motif (Sp1IIIT5A) remains underexplored. This study investigates the impact of Sp1IIIT5A on HIV...

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Literature Corpus work: 0024368a-e598-5dfc-a818-9a980911c0ce
DOI: 10.1101/2025.01.23.634640

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