Article

Dissecting the sources of variation in neuronally differentiated iPSC lines through multi-omics analysis

2026-06-10

Abstract excerpt

<h4>Summary</h4> Induced pluripotent stem cells (iPSCs) are widely used as patient-specific disease models, yet substantial unexplained variability in molecular and functional readouts limits their reliability. Here, we systematically investigated the sources of variation in iPSC-derived neurons for three rare genetic disorders: Myotonic Dystrophy Type 1, chromodomain-DNA-helicase-binding protein 2-related disord...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0016692c-647a-5535-88b9-62fe4fcc04ba
DOI: 10.64898/2026.06.10.731279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting the sources of variation in neuronally differentiated iPSC lines through multi-omics analysisDOI 10.64898/2026.06.10.731279Read

Multiomics Evaluation of Human iPSCs and iPSC-Derived NeuronsSemantic proximity Read

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility.Semantic proximity Read

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patientsSemantic proximity Read

Multi-omics Differential Inference for Functional Interpretation (MoDIFI): A Statistical Framework to Prioritize Cell Lines for Neurodevelopmental VariantsSemantic proximity Read

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.Semantic proximity Read

Comparative RNAseq analysis for the study of motoneuron diseases in multi-omics approachesSemantic proximity Read

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patientsSemantic proximity Read

A multi-omics approach to visualize early neuronal differentiation in 4DSemantic proximity Read

Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell LinesSemantic proximity Read

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.Semantic proximity Read

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiationSemantic proximity Read

The iPSC proteomic compendiumSemantic proximity Read