Article

Multimodal interrogation establishes the AAA+ ATPase RUVBL1 as a prognostic driver and tractable dependency in malignant pleural mesothelioma

2026-08-14

Abstract excerpt

<title>Abstract</title> <p>Malignant pleural mesothelioma (MPM) is an inexorably lethal malignancy, yet its therapeutic landscape remains largely devoid of actionable drivers. Here, by leveraging a stringent prioritization framework on genome-scale CRISPR dependency maps integrated with orthogonal molecular interrogation, we identify the AAA+ ATPase RUVBL1, an obligate component of the RUVBL1/2 complex, as a non-...

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Literature Corpus work: 001112ca-3f00-53a8-97de-38f8022e8b63
DOI: 10.21203/rs.3.rs-9380290/v1

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